Volume : 2, Issue : 6, JUN 2016
HEAD AND NECK CANCER ASSOCIATION WITH ALCOHOL
Dr. SWAPNA. K, Dr. G. SUDHAKAR
Abstract
BACK GROUND: Head and neck cancer is the common cancer in India occupying one-third place of all cancers. Due to more consumption of alcohol the parts like
oral cavity, pharynx and larynx have more probability to be affected with cancer.
AIM: Evaluated the association among gender, alcohol consumption and head and neck cancer.
MATERIALS AND METHODS: Between June 2011 and January 2013, 103 cases diagnosed with head and neck cancer were investigated. All subjects were interviewed
and examined according to the standardized protocol.
RESULTS AND DISCUSSION: Out of 65 males, 45 (69.23%) patients are alcohol drinkers, 19(29.23%) are non-drinkers and only one is ex drinker. But in females the ratio is different, drinkers are only one and non-drinkers are 37 (97.37%). Out of all non-drinkers are high with 56 (54.37%) followed by drinkers with 44.66% with its odds ratio and P value. It showed significant results.
CONCLUSION: In conclusion among alcohol drinkers, increasing consumption of alcohol was associated with increased risk of head and neck cancer in both men and women.
Keywords
pharynx, larynx, oral cavity and alcohol.
Article : Download PDF
Cite This Article
Article No : 15
Number of Downloads : 887
References
1. Baan R, Straif K, Grosse Y, et al. Carcinogenicity of alcoholic beverages. Lancet
Oncology 2007;8(4): 292-293.
2. Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S,
Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF., Jr Smoking and drinking in
relation to oral and pharyngeal cancer. Cancer Res. 1988;48:3282–3287.
3. Boyle, P., et al., European Code Against Cancer and scientific justification: third version
(2003). Ann Oncol, 2003. 14(7): p. 973-1005.
4. Castellsague X, Quintana MJ, Martinez MC, Nieto A, Sanchez MJ, Juan A, Monner A,
Carrera M, Agudo A, Quer M, Munoz N, Herrero R, Franceschi S, Bosch FX. The role
of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int J Cancer.
2004;108:741–749.
5. Chyou PH, Nomura AM, Stemmermann GN. Diet, alcohol, smoking and cancer of the
upper aerodigestive tract: a prospective study among Hawaii Japanese men. Int J Cancer
1995; 60:616–21.
6. Corrao, G., et al., A meta-analysis of alcohol consumption and the risk of 15 diseases.
Prev Med, 2004. 38 (5): p. 613-9.
7. Degenhardt, L., Hall, W., Teesson, M; & Lynskey, M. Alcohol Use Disorders in Australia:
Findings from the National Survey of Mental Health and Well Being. NDARC Technical
Report No. 97. National Drug and Alcohol Research Centre, New South Wales,
Australia, 1997.
8. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide
burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893–2917. doi:
10.1002/ijc.25516. pmid:21351269.
9. Fioretti F, Bosetti C, Tavani A, Franceschi S, Vecchia CL: Risk factors for oral and pharyngeal
cancer in never smokers. Oral Oncol 1999, 35:375-8.
10. Franceschi S, Bidoli E, Negri E, Barbone F, La Vecchia C. Alcohol and cancers of the
upper aerodigestive tract in men and women. Cancer Epidemiol Biomarkers Prev.
1994;3:299–304.
11. Gronbaek M, Becker U, Johansen D, Tonnesen H, Jensen G, Sorensen TI. Population
based cohort study of the association between alcohol intake and cancer of the upper
digestive tract. BMJ. 1998;317:844–847.
12. Hashibe M, Brennan P, Chuang SC, et al. Interaction between tobacco and alcohol use
and the risk of head and neck cancer: pooled analysis in the International Head and
Neck Cancer Epidemiology Consortium. Cancer Epidemiology, Biomarkers & Prevention
2009;18(2):541-550.
13. Hayes RB, Bravo-Otero E, Kleinman DV, Brown LM, Fraumeni JF, Jr, Harty LC, Winn
DM. Tobacco and alcohol use and oral cancer in Puerto Rico. Cancer Causes Control.
1999;10:27–33.
14. IARC, IARC Monographs on the evaluation of carcinogenic risks to humans. Volume
44 Alcohol drinking. 1988
15. International Agency for Research on Cancer. Alcohol Drinking. 1ARC Monographs
on the Evaluation of the Carcinogenic Risk to Humans, Vol.44. Lyon. France: IARC.
1988.
16. 15. IARC Monographs, Volume 100E: Personal habits and indoor combustions. 2012,
Lyon IARC Press p377 – 503.
17. Joffe, A. H. Alcohol and social complexity in ancient western Asia. Current Anthropology.
1998; 39, 297-322.
18. Kjaerheim K, Gaard M, Andersen A. The role of alcohol, tobacco, and dietary factors in
upper aerogastric tract cancers: a prospective study of 10,900 Norwegian men. Cancer
Causes Control. 1998;9:99–108.
19. L Addala, C Kalyana Pentapati, PK Reddy Thavanati, V Anjaneyulu, MD Sadhnani,
Risk factor profiles of head and neck cancer patients of Andhra Pradesh, India, Indian
Journal of Cancer, April-June 2012, Volume 49, Issue 2, 215-219.
20. Mayne ST, Morse DE, Winn DM. Cancers of the oral cavity and pharynx. In:
Schottenfeld D, Fraumeni JF Jr, editors. Cancer epidemiology and prevention. Oxford
University Press; New York: 2006. pp. 674–696.
21. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin.
2005;55:74–108.
22. Rehm, R., et al., Alcohol drinking cessation and its effect on esophageal and head and
neck cancers: A pooled analysis. Int J Cancer, 2007. 121(5): p. 1132-7.
23. Sanghvi LD, Rao DN, Joshi S. Epidemiology of head and neck cancer. Semin Surg
Oncol 1989;5:3059.
24. Sankaranarayanan R, Masuyer E, Swaminathan R, Ferlay J, Whelan S. Head and neck
cancer: A global perspective on epidemiology and prognosis. Anticancer Res
1998;18:4779-86.
25. Sturgis EM, Wei Q, Spitz MR. Descriptive epidemiology and risk factors for head and
neck cancer. Semin Oncol. 2004;31:726–733.
26. Takiar R, Nadayil D, Nandakumar A. Projections of number of cancer cases in India
(2010-2020) by cancer groups. Asian Pac J Cancer Prev 2010;11:1045-9
