Volume : 2, Issue : 9, SEP 2016

CAN ZINC AND MAGNESIUM DEFICIENCY LEAD TO LOW BIRTH WEIGHT?

Dr. Bilas Kumar Sarkar, Dr. Sujit Kumar Dey, Dr Sandeep Jain, Dr. Md Hefjur Rahaman, Dr. Jayanta Kumar Rout, Dr. Amrita Mukherjee

Abstract

Low birth weight babies (LBW) are a source of genuine concern and worry not only to clinicians but also to society at large. Developing countries like India suffer from a huge burden of malnourished mothers with numerous complications like preterm labour, small for date and pre-term babies. Nutritional factors are implicated in the pathogenesis of low birth weight babies. This study aims to evaluate association between important microelements like magnesium, zinc with low birth weight of infants. In our study we found that Magnesium and Zinc level was significantly low in TLBW infants when compared to TNBW infants, p value <0.005. We found a strong positive correlation between cord blood magnesium level (r= 0.369, p < 0.005) with the birth weight of term babies. There was a positive but weak correlation between cord blood zinc level and birth weight (r=0.178, p = 0.077). These findings suggest that zinc and magnesium have a significant impact on the growth and development of foetus and on the action of anabolic hormones. It also indicates that lower level of Mg, Zn hamper the growth and development of foetus. These findings can hypothesize that lower zinc and magnesium level, which can indicate maternal malnutrition and which can causes impairment in the action of the anabolic hormone, insulin and thus contributes to low birth weight.

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References

1. Rex-Kiss B, Szabo R. [Data and comments on the general validity of the weight limit of
2500 g for low-birth-weight infants]. Zentralbl Gynakol. 1984;106(18):1241-7.
2. Elizabeth KE, Krishnan V, Vijayakumar T. Umbilical cord blood nutrients in low birth
weight babies in relation to birth weight & gestational age. Indian J Med Res. 2008
Aug;128(2):128-33.
3. Takaya J, Kaneko K. Small for gestational age and magnesium in cord blood platelets:
intrauterine magnesium deficiency may induce metabolic syndrome in later life. J Pregnancy.
2011;2011:270474.
4. Thomas N, Grunnet LG, Poulsen P, Christopher S, Spurgeon R, Inbakumari M, et al.
Born with low birth weight in rural Southern India: what are the metabolic consequences
20 years later? Eur J Endocrinol. 2012 Apr;166(4):647-55.
5. Bharati P, Pal M, Bandyopadhyay M, Bhakta A, Chakraborty S. Prevalence and causes
of low birth weight in India. Malays J Nutr. 2011 Dec;17(3):301-13.
6. Rosen EU, Campbell PG, Moosa GM. Hypomagnesemia and magnesium therapy in
protein-calorie malnutrition. J Pediatr. 1970 Oct;77(4):709-14.
7. Hruby A, Meigs JB, O'Donnell CJ, Jacques PF, McKeown NM. Higher magnesium
intake reduces risk of impaired glucose and insulin metabolism and progression from
prediabetes to diabetes in middle-aged americans. Diabetes Care. 2014 Feb;37(2):419-
27.
8. Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin
Resistance in Type 2 Diabetes Mellitus. J Lab Physicians. 2015 Jul-Dec;7(2):75-8.
9. Ziniewicz HK, Gesteiro E, Gonzalez-Munoz MJ, Bastida S, Sanchez-Muniz FJ. Relationships
between Serum Calcium and Magnesium Levels and Lipoproteins,
Homocysteine and Insulin Resistance/Sensitivity Markers at Birth. Nutr Hosp.
2014;31(n01):278-85.
10. Marreiro DN, Geloneze B, Tambascia MA, Lerario AC, Halpern A, Cozzolino SM.
[Role of zinc in insulin resistance]. Arq Bras Endocrinol Metabol. 2004 Apr;48(2):234-
9.
11. El Dib R, Gameiro OL, Ogata MS, Modolo NS, Braz LG, Jorge EC, et al. Zinc
supplementation for the prevention of type 2 diabetes mellitus in adults with insulin
resistance. Cochrane Database Syst Rev. 2015;5:CD005525.
12. Ahn BI, Kim MJ, Koo HS, Seo N, Joo NS, Kim YS. Serum zinc concentration is
inversely associated with insulin resistance but not related with metabolic syndrome in
nondiabetic Korean adults. Biol Trace Elem Res. 2014 Aug;160(2):169-75.
13. Lamberti LM, Fischer Walker CL, Black RE. Zinc Deficiency in Childhood and Pregnancy:
Evidence for Intervention Effects and Program Responses. World Rev Nutr
Diet. 2016;115:125-33.
14. Zajac J, Boznanski A. [Role of zinc in carbohydrate metabolism]. Pol Tyg Lek. 1991
Jun 10-24;46(24-26):474-5.
15. Herington AC. Effect of zinc on the binding and action of growth hormone in isolated
rat adipocytes. Biochem Int. 1985 Dec;11(6):853-62.
16. Singh RB, Niaz MA, Rastogi SS, Bajaj S, Gaoli Z, Shoumin Z. Current zinc intake and
risk of diabetes and coronary artery disease and factors associated with insulin resistance
in rural and urban populations of North India. J Am Coll Nutr. 1998
Dec;17(6):564-70.
17. Thind GS, Fischer GM. Plasma cadmium and zinc in human hypertension. Clin Sci
Mol Med. 1976 Nov;51(5):483-6.
18. Kedracka J, Zawitkowski J. [Zinc and copper levels in essential hypertension (author's
transl)]. Ann Univ Mariae Curie Sklodowska Med. 1975;30:191-4.
19. Thind GS, Fischer GM. Relationship of plasma zinc to human hypertension. Clin Sci
Mol Med. 1974 Jan;46(1):137-41.
20. Kazemi-Bajestani SM, Ghayour-Mobarhan M, Ebrahimi M, Moohebati M, Esmaeili
HA, Parizadeh MR, et al. Serum copper and zinc concentrations are lower in Iranian
patients with angiographically defined coronary artery disease than in subjects with a
normal angiogram. J Trace Elem Med Biol. 2007;21(1):22-8.
21. Tiber AM, Sakhaii M, Joffe CD, Ratnaparkhi MV. Relative value of plasma copper,
zinc, lipids and lipoproteins as markers for coronary artery disease. Atherosclerosis.
1986 Nov;62(2):105-10.
22. Declaration of Helsinki. Ethical principles for medical research involving human subjects.
J Indian Med Assoc. 2009 Jun;107(6):403-5.
23. Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz Textbook
of Clinical Chemistry and Molecular Diagnostics. 4th ed. New Delhi:
Saunders,Elsevier; 2006. p. 870-1.
24. Cohen SA, Daza IE. Calmagite method for determination of serum magnesium modified.
Clin Chem. 1980 May;26(6):783.
25. Khoushabi F, Shadan MR, Miri A, Sharifi-Rad J. Determination of Maternal Serum
Zinc, Iron, Calcium and Magnesium during Pregnancy in Pregnant Women and Umbilical
Cord Blood and Their Association with Outcome of Pregnancy. Mater Sociomed.
2016 Apr;28(2):104-7.
26. Gomez T, Bequer L, Mollineda A, Gonzalez O, Diaz M, Fernandez D. Serum zinc levels
of cord blood: relation to birth weight and gestational period. J Trace Elem Med
Biol. 2015 Apr;30:180-3.
27. Bogden JD, Thind IS, Kemp FW, Caterini H. Plasma concentrations of calcium, chromium,
copper, iron, magnesium, and zinc in maternal and cord blood and their relationship
to low birth weight. J Lab Clin Med. 1978 Sep;92(3):455-62.
28. Akman I, Arioglu P, Koroglu OA, Sakalli M, Ozek E, Topuzoglu A, et al. Maternal zinc
and cord blood zinc, insulin-like growth factor-1, and insulin-like growth factor binding
protein-3 levels in small-for-gestational-age newborns. Clin Exp Obstet Gynecol.
2006;33(4):238-40.
29. Sherwani S, Hasnain N, Qadir U. Magnesium status in maternal and cord blood. J Pak
Med Assoc. 1998 Feb;48(2):32-4.
30. Takaya J, Yamato F, Higashino H, Kobayashi Y. Relationship of intracellular magnesium
of cord blood platelets to birth weight. Metabolism. 2004 Dec;53(12):1544-7.