Volume : 11, Issue : 2, FEB 2025

NATIONAL CONFERENCE ON “ROLE OF BIOTECHNOLOGY IN AGRICULTURE, CHEMICAL, PHYSICAL, AND ENVIRONMENTAL SCIENCES FOR SUSTAINABLE DEVELOPMENT” (NCB-2025)

ANTICANCER POTENTIAL OF NANO-METAL COMPLEXES: A PROMISING AVENUE FOR TARGETED THERAPY

AVINASH RANI, JYOTI SHARMA*, GURDEEP SANGWAN

Abstract

Nano-metal complexes have emerged as innovative tools in the fight against cancer due to their unique physicochemical properties, enhanced bioavailability, and targeted delivery capabilities. This study explores the synthesis, characterization, and biological evaluation of nano-metal complexes for anticancer applications. The complexes were prepared using biocompatible ligands and characterized using advanced spectroscopic and imaging techniques. In vitro cytotoxicity assays demonstrated significant anticancer activity against various human cancer cell lines, including SH-SY-5Y neuroblastoma cells. Molecular docking studies revealed strong interactions with key biomolecular targets, supporting their mechanism of action. Additionally, DNA cleavage studies confirmed their ability to induce DNA damage, further validating their therapeutic potential. These findings highlight the promise of nano-metal complexes as effective, targeted anticancer agents, paving the way for their development in clinical applications.

Article : Download PDF

Cite This Article

-

Article No : 3

Number of Downloads : 799

References

1. Baskar, R., Lee, K.A., Yeo, R. and Yeoh, K.W., 2012. Cancer and radiation therapy: current advances and future directions. International journal of medical sciences, 9(3), p.193.https://doi.org/10.7150/ijms.3635.

2. Joseph, T.M., Kar Mahapatra, D., Esmaeili, A., Piszczyk, ?., Hasanin, M.S., Kattali, M., Haponiuk, J. and Thomas, S., 2023. Nanoparticles: Taking a unique position in medicine. Nanomaterials, 13(3), p.574.https://doi.org/10.3390/nano13030574.

3. Gamberi, T. and Hanif, M., 2022. Metal-based complexes in cancer treatment. Biomedicines, 10(10), p.2573. https://doi.org/10.3390/ijms24087289.

4. Villalobos Gutierrez, P.T., Patakfalvi, R., Hernández, A.D.S., Carrillo, J.L.M., Paredes, J.M.V., Salazar, C.S. and Coronado, O.G., 2024. The Role of Noble Metal Nanomaterials in Cancer Therapy. https://doi.org/10.1007/16833_2024_442

5. Catalano, E., 2019. Superparamagnetic iron oxide nanoparticles conjugated with doxorubicin for targeting breast cancer. arXiv preprint arXiv:1911.05378. https://doi.org/10.48550/arXiv.1911.05378

6. Pena, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H.W., Metselaar, J.M., Kiessling, F., Pallares, R.M., Wuttke, S. and Lammers, T., 2022. Metallodrugs in cancer nanomedicine. Chemical society reviews, 51(7), pp.2544-2582.https://doi.org/10.1039/D1CS00468A.

7. Alessio, E. and Guo, Z., 2017. Metal anticancer complexes–activity, mechanism of action, future perspectives. European journal of inorganic chemistry, 2017(12), pp.1539-1540.

8. Jia, S., Wang, R., Wu, K., Jiang, H. and Du, Z., 2019. Elucidation of the mechanism of action for metal based anticancer drugs by mass spectrometry-based quantitative proteomics. Molecules, 24(3), p.581.

9. Nath, P., Datta, A. and Adhikari, S., 2022. Recent advances of metal-based anticancer agents and their in vivo potential against various types of malignancies. Handbook of animal models and its uses in cancer research, pp.1-28.

10. Gautier, A. and Cisnetti, F., 2012. Advances in metal–carbene complexes as potent anti-cancer agents. Metallomics, 4(1), pp.23-32.

11. Mejia, C., Ortega-Rosales, S. and Ruiz-Azuara, L., 2018. Mechanism of action of anticancer metallodrugs. Biomedical applications of metals, pp.213-234.

12. Ha Lien, N.T., Phan, A.D., Van Khanh, B.T., Thuy, N.T., Trong Nghia, N., My Nhung, H.T., Hong Nhung, T., Quang Hoa, D., Duong, V. and Minh Hue, N., 2020. Applications of mesoporous silica-encapsulated gold nanorods loaded doxorubicin in chemo-photothermal therapy. ACS omega, 5(32), pp.20231-20237. https://doi.org/10.48550 /arXiv.2007.11760

13. Catalano, E. and Di Benedetto, A., 2017, May. Characterization of physicochemical and colloidal properties of hydrogel chitosan-coated iron-oxide nanoparticles for cancer therapy. In Journal of Physics: Conference Series (Vol. 841, No. 1, p. 012010). IOP Publishing.https://doi.org/10.48550/arXiv.1706.02590.

14. Xie, Z., Chen, S., Liu, Q., Lin, Z., Zhao, J., Fan, T., Liu, L., Bao, S., Fan, D. and Zhang, H., 2018. Biocompatible Two-dimensional Titanium Nanosheets for Efficient Plasmonic Photothermal Cancer Therapy. arXiv preprint arXiv:1805.01976.https://doi.org/10.48550/arXiv.1805.01976

15. Ma, S., Chen, L., Hamza, M., Chang, J. and Zhu, M., 2023. Regulating metalloimmunology with nanomedicine for cancer therapy. Nano Research, 16(12), pp.13164-13181. https://doi.org/10.1007/s12274-023-6212-y.