Volume : 9, Issue : 5, MAY 2023

REVIEW ON EFFECTS OF LOW LEVEL LASER THERAPY ON NERVE REGENERATION IN DIABETIC PERIPHERAL NEUROPATHY SUBJECTS.

DR. J ANANDH RAJ, DR. M L RAMYA KRISHNA

Abstract

One of the most major complications of diabetes mellitus is Diabetic peripheral neuropathy where it is related to micro and macro-vascular structures. The estimation of DPN prevalence in India was varied widely from 9.6% to 78% in different populations. Low-level laser therapy (LLLT) has a great contribution of nerve regeneration in diabetic neuropathy. The study is to review the literature regarding LLLT in treating neuropathic pain. The objective of the study was to review literature to find the effect of laser therapy in nerve regeneration and also to investigate the intimate relationship with tissue recovery in peripheral neuropathy. The main aim of this article to review the influence of low level laser therapy on nerve regeneration in diabetic neuropathy. Materials and Methods: The search was done in PubMed/Medline, Google scholar and list of bibliographic references of article from 2004 to 2021 with keywords: low level laser therapy, nerve regeneration, diabetic neuropathy. In database up to 10 article were selected in search engine with the use of keywords which is relevant to the study. As per literature review it states that the laser therapy accelerates nerve regeneration, release of neural factors, release of growth factor,  reduce inflammation, pain, increases vascular permeability. But there are controversy in parameter like wavelength, type, energy density, power and frequency of treatment. Conclusion of the literature review there is improvement in nerve regeneration and  function with laser  therapy in diabetic neuropathy.

Keywords

LOW LEVEL LASER THERAPY, NERVE REGENERATION, DIABETIC PERIPHERAL NEUROPATHY.

Article : Download PDF

Cite This Article

-

Article No : 6

Number of Downloads : 581

References

1. Tavakoli M, Mojaddidi M, Fadavi H, Malik RA.,(2008) Pathophysiology and treatment of painful diabetic neuropathy. Curr Pain Headache Rep;12(3):192–7.

2. Young MJ, Veves A, Walker MG, Boulton AJ., (1992)Correlations between nerve function and tissue oxygenation in diabetic patients: further clues to the aetiology of diabetic neuropathy. Diabetologia;35(12):1146–50.

3. Head KA., (2006) Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev;11(4):294–329.

4. Schindl A, Schindl M, Schon H, Knobler R, Havelec L, Schindl (1998) Low-intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Diabetes Care;21(4):580–4.

5. Davies M, Brophy S, Williams R, Taylor A.( 2006) The prevalence, severity and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care;29(7):1518–22.

6. Dworkin RH, O’Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, et al. 2007 Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain;132(3):237–51.

7. Buaisha BB, Costanzi JB, Boulton AJ. (1998) Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: a long-term study. Diabetes Res Clin Pract;39(2):115–21.

8. Leonard DR, Farooqi MH, Myers S. (2004) Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebocontrolled study with monochromatic near-infrared treatment. Diabetes Care;27(1):168–72.

9. Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V. (2004) Low intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care;27(4):921–4.

10. Peric Z, Cvetkovic B.,2006  Electrophysiological evaluation of low intensity laser therapy in patients with diabetic polyneuropathy. Facta Universitats;13:11–4.

11. Weintraub MI, Wolfe GI, Barohn RA, Cole SP, Parry GJ, Hayat G, et al. (2003) Static magnetic field therapy for symptomatic diabetic neuropathy: a randomized, double-blind, placebo controlled trial. Arch Phys Med Rehabil;84(5):736–46.

12. Wro´ bel MP, Szymborska Kajanek A, Wystrychowski G, Biniszkiewicz T, Sieron´ Stotny K, Sieron´ A, et al, (2008) Impact of low frequency pulsed magnetic fields on pain intensity, quality of life and sleep disturbances in patients with painful diabetic polyneuropathy. Diabetes Metab;34(4):349–54.

13. Kumar D, Marshall HJ, (1997) Diabetic peripheral neuropathy: amelioration of pain with transcutaneous electrostimulation. Diabetes Care;20(11):1702–5.

14. Hamza MA, White PF, Craig WF, Ghoname ES, Ahmed HE, Proctor TJ, et al.(2000) Percutaneous electrical nerve stimulation: a novel analgesic therapy for diabetic neuropathic pain. Diabetes Care;23(3):365–70.

15. Tesfaye S, Watt J, Benbow SJ, Pang KA, Miles J, MacFarlane IA.(1996) Electrical spinal-cord stimulation for painful diabetic peripheral neuropathy. Lancet;348(9043):1698–701.

16. Rochkind S, Ouaknine GE.1992 New trend in neuroscience: lowpower laser effect on peripheral and central nervous system (basic science, preclinical and clinical studies). Neurol Res;14(1):2–11.

17. Rochkind S. (2009) Phototherapy in peripheral nerve regeneration: from basic science to clinical study. Neurosurg Focus;26(2):E8.

18. Rochkind S, Nissan M, Razon N, Schwartz M, Bartal A, (1986) Electrophysiological effect of HeNe laser on normal and injured sciatic nerve in the rat. Acta Neurochir (Wien);83(3- 4):125– 0.

19. Rochkind S, Nissan M, Lubart R, Avram J, Bartal A.(1988) The invivo- nerve response to direct low-energy-laser irradiation. Acta Neurochir (Wien);94(1-2):74–7.

20. Anders JJ, Borke RC, Woolery SK, Van de Merwe WP, (1993) Low power laser irradiation alters the rate of regeneration of the rat facial nerve. Lasers Surg Med;13(1):72–82.

21. Barbosa RI, Marcolino AM, de Jesus Guirro RR, Mazzer N, Barbieri CH, de Ca´ ssia Registro Fonseca M. (2010) Comparative effects of wavelengths of low-power laser in regeneration of sciatic nerve in rats following crushing lesion. Lasers Med Sci;25(3):423–30.

22. Martínez de Albornoz, P, Delgado, P.J. Forriol, F. Maffulli, N.,(2011)Non-surgical therapies for  eripheral nerve injury. Br. Med. Bull., 100, 73–100.

23. Ziago, E.K.; Fazan, V.P.; Iyomasa, M.M.; Sousa, L.G.; Yamauchi, P.Y.; da Silva, E.A.;  orie, E.; Fuentes, R.; Dias, F.J. (2017)Analysis of the variation in low-level laser energy density on the crushed sciatic nerves of rats: A morphological, quantitative, and morphometric study. Lasers Med. Sci., 32, 369–378.

24. Gigo-Benato, D.; Geuna, S.; Rochkind, S. (2005)Phototherapy for enhancing peripheral nerve repair: A review of the literature. Muscle Nerve, 31, 694–701.

25. Hashmi, J.T.; Huang, Y.Y.; Osmani, B.Z.; Sharma, S.K.; Naeser, M.A.; Hamblin, M.R. (2010)Role of low-level laser therapy in neurorehabilitation. PM&R, 2, 292–305.

26. Ginani, F.; Soares, D.M.; Barreto, M.P.; Barboza, C.A. (2015)Effect of low-level laser therapy on mesenchymal stem cell proliferation: A systematic review. Lasers Med. Sci., 30, 2189– 194.

27. Khamseh, M. E., Kazemikho, N., Aghili, R., Forough, B., Lajevardi, M., Dabaghian, F. H., ... & Malek, M. (2011). Diabetic distal symmetric polyneuropathy: effect of low-intensity laser therapy. Lasers in medical science,  26(6), 831-835.

28. Anju, M., Chacko, L., Chettupalli, Y., Maiya, A. G., & Ummer, V. S. (2019). Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy–A pilot study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), 1087-1091.

29. Wang, C. Z., Chen, Y. J., Wang, Y. H., Yeh, M. L., Huang, M. H., Ho, M. L., ... & Chen, C. H. (2014). Low-level laser irradiation improves functional recovery and nerve regeneration in sciatic nerve crush rat injury model. PloS one, 9(8), 10334-8.

30. Akgul, T., Gulsoy, M., & Gulcur, H. O. (2014). Effects of early and delayed laser application on nerve regeneration. Lasers in medical science, 29(1), 351-357.

31. Zinman, L. H., Ngo, M., Ng, E. T., Nwe, K. T., Gogov, S., & Bril, V. (2004). Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care, 27(4), 921-924.

32. Cg, S. K., Maiya, A. G., Hande, H. M., Vidyasagar, S., Rao, K., & KV, R. (2015). Efficacy of low level laser therapy on painful diabetic peripheral neuropathy. Laser therapy24(3), 195-200.

33. Yamany, A. A., & Bitesha, K. (2016). Effect of 850 nm He-Ne laser therapy on nerve conduction and foot planter pressures distribution of painful diabetic neuropathy: a randomized controlled trial. J Nov Physiother6(4), 300.

34. Bashiri, H. (2013). Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta Medica Iranica, 543-547.

35. Suganthirababu, P., BV, S. S., Prathap, L., & Jannu, C. (2018). Low-level Laser Therapy in the Management of Diabetic Sensorimotor Polyneuropathy. Indian Journal of Public Health Research & Development9(12).

36. Prathap, S., Maiya, A., & Saraswathi, J. D. (2011). Effect of low level laser irradiation on motor nerve conduction velocity of experimentally induced diabetic neuropathy in wistar rat. Journal of Pharmaceutical and Biomedical Sciences (JPBMS)13(13).