Volume : 1, Issue : 1, NOV 2015


Sadaf Ali, Zubair Ahmed, Aftab Ahmad, Shah Alam Khan, Asif Husain


Insomnia is the most common sleeping disorder affecting population with or without other medical or psychiatric disorders. It affects more than 30% of the adult population and causes wide range of health problems like hypertension, obesity, diabetes, heart attack and stroke. Despite the availability of a number of drugs, insomnia is still a serious medical issue. The orexin (OX and OX ) receptors are G-protein-coupled receptors 1 2 which have key roles in the regulation of sleep-wake cycles. Suvorexant (also known as MK-4305) is a selective, dual orexin receptors antagonist, R used in the treatment of insomnia. Suvorexant is available in the market under the brand name of Belsomra . Suvorexant is considered as an effective treatment for insomnia, and reported to be well-tolerated by patients. This review presents updated information on the pharmaceutical and pharmacological description of Suvorexant.


Belsomra, Sleep disorder, receptor, hypocretin

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