Volume : 3, Issue : 11, NOV 2017

OCULAR MALIGNANT MELANOMA BRAF V600E MUTATION, TREATED WITH TARGETED MOLECULAR TREATMENT, WITH MULTIPLE METASTASIS - CASE REPORT

CRISTINA MARIA MARGINEAN, M.S. POPESCU, M. VLADAIA, DIANA RODICA TUDORASCU, F. PETRESCU

Abstract

Malignant melanoma is a rare disease but also the most common primary ocular neoplasia. The origin is represented by melanocytar cells wich serve the function of producing melanine that determines the eye color. Uveal malignant melanoma is associated with increased risk of secondary metastasis. Choroid melanoma has the least favorable prognosis. The diagnosis is most often accidental durring a rutine checkup, usually the patient is asymptomatic, the only signs that can be present are local pain and visual imparement. We will present the case of a 31 year old male, diagnosed with uveal malignant melanoma of the left eye, by histopathologic examination and immunohistochemistry investigation of the biopsy piece. The patient is under treatment with Dabrafenib, Tramatinib and targeted palliative photon radiotherapy, with unfavorable evolution and multiple metastasis.

Keywords

Malignant Melanoma, Uveal, BRAF V600E Mutation, Metastasis, Targeted Molecular Treatment.

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