Volume : 2, Issue : 8, AUG 2016

ISOLATION, SEPARATION AND DOCKING ANALYSIS OF ? CAROTENE AND LYCOPENE FROM VARIOUS FRUITS AND VEGETABLES

Dr. Mrs. Radha, A. M. Sylaja

Abstract

Cancer is the leading cause of death today and mostly in developed countries. Regular consumption of fruits and vegetables is associated with reduced risks of Cancer, Cardiovascular diseases, Stroke, Alzheimer's disease, Cataract etc. Prevention is more effective strategy then is the treatment of chronic disease .Functional foods that contain significant amount of bioactive components that may provide desirable health benefits beyond basic nutrition and play an important role in prevention of chronic diseases. The literature survey revealed that intake of antioxidants like beta Carotene, Vitamin C ,Vitamin E etc reduce oxidative stress induced carcinogenesis .Keeping this in view the study of qualitative analysis of antioxidants β-carotene and Lycopene in various fruits and vegetable sources are investigated. The biological work involved in isolating the antioxidants from different sources like tomato, red pepper, spinach, yellow pepper, carrot and papaya, separating the isolated samples by thin layer chromatography. The docking studies of β-carotene and Lycopene with EGFR receptor was carried out which indicated their effect of mitigating the symptoms of lung cancer. Study showed that the binding efficiency of β Carotene is much better than Lycopene.

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