Volume : 5, Issue : 7, JUL 2019
FORMULATION, EVALUATION AND OPTIMIZATION OF FAST DISINTEGRATING NIFEDIPINE 5 MG. TABLET BY DIRECT COMPRESSION METHOD
JAMEEL ABBAS, ANSARI YAASIR AHMED, DR. MALIK TAUHEED AHMAD, DR. SAYED ISAR AHMAD, SAYYED MUKHIM, MOHD FAROOQUE
The most common preferred route is oral rout of administration. Today oro-dispersible tablet from novel drug delivery system
gain importance from patient. Which is administer to the patient to control the attack of angina or hypertension, but for
immediate control, Oro-dispersible tablet is oral solid dosage form in which the tablet gets dispersed in oral cavity in absence
of water. Various manufacture are formulated this formulation by various method. The most importance thing in this
formulation are masking of taste of drugs. Generally oro-dispersible tablet are prepared by direct compression method. Dry
granulation, wet granulation, Spry drying is the various methods for preparation of oro-dispersible tablet. Oro-dispersible
tablet generally contains filler, glidant, anti-adherent super disintegrate, sweetener and resins. Evaluation parameter includes
hardness, friability, wetting time, moisture uptake, disintegration test, and dissolution test. Wetting time, Disintegration time,
and Dissolution test is directly proportional to the hydrophobic ingredient added for lubrication, anti-adherent, Glidant action.
These hydrophobic ingredient are Magnesium Stearate. To oppose the action of magnesium stearate, hydrophilic additives are
incorporated viz Sodium lauryl sulphate, Cross carmillose sodium, sodium starch glycol ate are added.
ORO-DISPERSIBLE TABLET, WETTING TIME, DISSOLUTION TEST.
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