Volume : 5, Issue : 7, JUL 2019




Tablet among the all dosage form is the common one and in the Pharmacy it is the mother of Pharmacy. Generally tablet are
accepted in all category of patient. In children Dispersible form and in female for virginal infection virginal form are the
preferred. The most common preferred route is oral rout of administration. In ancient Ayurveda, Unani, Greek, Egyptian
remedies drug in the form of Churna, Bhasma, Gutika, Araka, are administered though oral rout. Pills which are coated by
natural resinous material are administered in the form of tablet through oral rout.
Today oro-dispersible tablet from novel drug delivery system gain importance from patient. Which is administer to the patient
to control the various immediate action viz. attack of angina or hypertension in cardiac problems. Orodispersible tablet gets
dispersed in oral cavity in absence of water and release fast drug which result fast pharmacological action. In the market drug
from Analgesic, Antipyretic, Antihypertensive and many more are available in the form of the orodispersible tablet. Various
manufacture are formulated this formulation by various method. The most importance thing in this formulation are masking
of taste of drugs. Generally oro-dispersible tablet are prepared by direct compression method. Dry granulation, wet
granulation, Spry drying is the various methods for preparation of oro-dispersible tablet. Oro-dispersible tablet generally
contains filler, glidant, anti-adherent super disintegrate, Flavoring agent sweetener and resins. Evaluation parameter includes
hardness, friability, wetting time, moisture uptake, disintegration test, and dissolution test. Wetting time, Disintegration time,
and Dissolution test is directly proportional to the hydrophobic ingredient added for lubrication, anti-adherent, Glidant action.
These hydrophobic ingredient are Magnesium Stearate. To oppose the action of magnesium stearate, hydrophilic additives are
incorporated viz Sodium lauryl sulphate.
From Marketing point of view special Marketing Executive team required to promote the new technique , new formulation
with demonstration to the Cardiac Surgeon, Pediatrics, Orthopedics, Gynecologists, Ophthalmologists, Urologist. After
demonstration that how to use the Orodispersible tablet these marketing team personally serve to the new admitted patients.



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1. United State Pharmacopoeia -30, National Formulary - 25, 2007, By Authority of the United State Pharmacopoeia Convention, Inc. Prepared by the Council of Experts and Published the Board of Trustees,pp.1456, 2569. 2. Christina Osei-Asare, Samuel Lugrie Kipo, Kwabena Ofori-Kwakye*, Mariam El Boakye-Gyasi 2015. Journal of Applied Pharmaceutical Science, Vol. 5 (08), pp. 054-060. 3. Ayyaj A. Badgire, Syed Abdul Azeem A., Shoeb Qazi, Ansari Yaasir Ahmed,Rahil Meman 2019. Comparative Study On Solubility Enhancement Methods For Mefenamic Acid And Its Formulation And Evaluation, International Journal of Research in Advent technology, Vol. 7, No.7, pp. 74-81. 4. Umme Rumana U.G, Ansari Yaasir Ahmed, Dr.G.J Khan, Shoeb Quazi, Syed Abdul Azeem 2019. Formulation And Evaluation Of Mouth Dissolving Tablet Of Cefixime Trihydrate, International Journal of Research in Advent technology, Vol. 7, No.7, pp. 54-61. 5. "Nifedipine Pregnancy and Breastfeeding Warnings". Archived from the original on 21 December 2015. Retrieved 25 December 2015. Corey, E.J. (2013). Drug discovery practices, processes, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 172. 6. Fischer, Jnos, Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 464. 7. "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016. 8. "Nifedipine". International Drug Price Indicator Guide. Retrieved 25 December 2015. 9. Zajc, N., Obreza, A., Beleb, M., et al 2005. Physical properties and dissolution behavior of Nifedipine / Mannitol co-precipitates prepared by hot melt method, Int J Pharm, 291(1-2), pp. 51-58. 10. Rajebahadur, M., Zia, H., Nues, A., et al 2006. Mechanistic study of solubility enhancement of Nifedipine using vitamin E TPGS or solutol HS-15, Drug Deliv, 13(3), pp. 201-206. 11. Sardari, F., Jouyban, A. 2013. Solubility of Nifedipine in ethanol + water and propylene glycol + water mixtures at 293.2 to 313.2 K. Ind Eng Chem Res, 52(40), pp. 14353-14358. 12. Law, S.L., Lo, W.Y., Lin, F.M., et al 2015. Dissolution and absorption of Nifedipine in polyethylene glycol co-precipitate containing phosphatidylcholine, Int J Pharm, 84, pp.161-166. 13. Indian Pharmacopoeia 2007. Government of India Ministry of Health & Family Welfare, Published By the Indian Pharmacopoeia Commission, Ghaziabad. Volume 1st, pp. 477-478, 177-183. 14. British Pharmacopoeia 2005. Published by The stationery office on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA), Volume 1st, pg.11. 15. Tejaswi Annapureddy, J. Padma preetha1, Dr. N. Arun Kumar 2013. Enhancement of Solubility of Nifedipine by Liquisolid Compacts Technique”. Indo American Journal of Pharmaceutical Research, 3(4). 16. Christina Osei-Asare, Samuel Lugrie Kipo, Kwabena Ofori-Kwakye*, Mariam El Boakye-Gyasi 2015. Compretive in vitro dissolution of commercially available sustained release Nifedipine tablet. Journal of applied pharmaceutical science vol.5 (8), pp. 054 -060. 17. Dr. Om Parkash Gaddgeppa, Sachin Gholve 2015. Formulation and evaluation of fast disintegrating tablets of Nifedipine by QbD Approach, International journal of pharmacy and pharmaceutical research, vol.4 issue No. 3.