Volume : 4, Issue : 3, MAR 2018

BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN RELATION TO INFECTED PATIENTS WITH BRUCELLA SPECIES AT KING FAHD HOSPITAL, RIYADH, SAUDI ARABIA.

FAISAL ALMAJED, FARRAJ AL-QAHTANI, FEDA ALJASER, HAZEM AQEL, SAMEERA AL-JUHANI, SHOEB QURESHI

Abstract

Objectives To determine the prevalence and the intensity of infection with Brucella species among patients of different ages and sex at different months, and to evaluate the efficacy in normalizing the levels of some biochemical and hematological blood results. Methods This study was carried out at the Clinical Labs (Microbiology, Serology, Hematology and Biochemistry Departments) at King Fahd Hospital, King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. Results A total of 79 patients infected with Brucella were enrolled in this study. Males were outnumbered the females, 74.68% vs. 25.32%. Of the total number of isolates, 30 (37.97%) were from patients 46-71 years of age and 26 (32.91%) were from patients <20 years of age. The most common hematological changes observed wereeosinopenia (91.14), monocytosis (29.1), anemia (22.8%), leukocytosis (15.2%), lymphocytosis (8.9%), leucopenia (7.6%), and lymphopenia (1.27%). Patients showed an increase in ESR level by 67.1%. The biochemical changes includeda decline in sodium (54.4%), creatinine (19%), albumin (12.7%), and potassium (5.1%), however the total bilirubin was found to be elevated (6.33%). The patients showed increased serum aspartate transaminase(AST; 43.04%) and alanine transaminase(ALT; 27.85%). Conclusion Brucella disease causes significant hematological changes, and could lead to hepatic dysfunction. Despite the high incidence and serious nature of the hematological changes and liver involvement, these changes could be transient and responded favorably to a proper antimicrobial therapy.

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